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Antibody to SARS-CoV-2 inhibits complement hyperactivation – News-Medical.Net

Although several monoclonal antibodies against the SARS-CoV-2 spike protein have been developed and clinically tested, little is known about antibodies to the nucleocapsid…

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Researchers identified several antibodies to the nucleocapsid protein from a convalescent COVID-19 patient. Tests found some can inhibit complement hyperactivation and could potentially lead to new therapeutics.
Approximately half of all patients with severe COVID-19 disease develop acute respiratory distress, which can be fatal. Some patients also have symptoms similar to acute respiratory distress syndrome (ARDS). Studies have suggested that a hyperactive complement system, a part of the immune…

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